Serotonin And Its Unusual Role In The Brain
Serotonin And Its Unusual Role In The Brain.
What is Serotonin?
Serotonin is a monoamine neurotransmitter also called 5-hydroxytyptamine. It is derived from the essential amino acid L-tryptophan – ‘essential’ meaning the body can’t create it itself, therefore we need to obtain our from the foods we eat. Serotonin is generally involved in the body’s sleep wake cycles, appetite and reward centre. Although there are 7 different families of serotonin receptors and 14 sub-types found all throughout the body where can produce adverse effects. We won’t delve into all of these, though we will explore its involvement in the reward centre and how it makes us feel good when coupled with dopamine. Our main focus is serotonin, though dopamine is closely linked.
Where Do You Find Serotonin?
There is a lot of serotonin stored in หากคุณสนใจเล่นพนันออนไลน์ที่ดีที่สุด สามารถสมัครสมาชิก UFABET ได้ที่นี่ พร้อมรับโปรโมชั่นพิเศษสำหรับสมาชิกใหม่ the enterochromaffin cells found in the tissue around the gastrointestinal tract (GIT). In the gut about 90% of it is synthesise and stored. While some is also stored in and travels in blood platelets. The other 10% is found in the brain stem. Where it is produced in the raphe nuclei and stored there in vesicles as it awaits release.
From the brain stem, there are over 20 known serotonergic pathways all throughout the brain travelling to and through the following neural structures:
- Accumbens (ACN)
- Hypothalamus (HYP)
- Substantia Nigra (SN)
- Ventral Pallidum
- Substantia Nigra
- Ventral Tegmental Area
- Vagus Nerve
- Cerebellum
- Cortex
- Frontal Cortex
- Dorsal Vagal Complex
- Hypoglossal Nerve
- Choroid Plexus
- Olfactory Tubercle
- Limbic System
The last one is important as its effects in the limbic system means it has a large role in anxiety, depression and mood regulation.
Well, How Is Made and Where Do We Get It From?
The body has no way to naturally produce. So therefore it is synthesised through amino acids consumed. 5-HT is derived from the amino acid L-Tryptophan through a process of hydration via the enzyme L-tryptophan hydroxylase and then naturally undergoes a decarboxylation process (the body forms carbon dioxide and water) to create.
